New product enables high DNA library complexity from low-quality samples
at industry-leading conversion rates
CORALVILLE, Iowa (February 19, 2020)
– Integrated DNA Technologies (IDT), a leading comprehensive genomics solutions provider, has launched the xGen Prism DNA Library Prep Kit
, designed to produce high-quality Next Generation Sequencing (NGS) data from precious but challenging samples, assisting in the early detection of cancer mutations and other applications.
The xGen Prism DNA Library Prep Kit uses a proprietary strategy that maximizes sample conversion at industry-leading rates. The kit is designed to convert DNA from cell-free DNA and formalin-fixed paraffin-embedded (FFPE) tissues into high-quality NGS libraries. This high performance is important for sensitive applications that depend on the detection of single nucleotide variants (SNVs) in low-quality samples, including oncology samples that are especially difficult to evaluate.
Trey Martin, President of IDT said, “The xGen Prism DNA Library Kit is an outstanding addition to our comprehensive NGS portfolio. IDT’s unique approach for the Prism kit is an entirely new technology that turns difficult, low-quality samples into high-quality data. This solves the ‘needle in a haystack’ challenge faced by genomics researchers looking for DNA variants that can help determine the frequency and severity of tumor mutations.”
IDT’s new kit pairs a novel ligase and highly-modified adapters to virtually eliminate adapter dimers, a common cause of reduced sequencing throughput. Reducing dimers means more usable data from each sequencing run. The xGen Prism DNA Library Prep Kit is also highly accurate, allowing the detection of ultra-low frequency variants. Unique molecular identifier (UMI) sequences are incorporated during single-stranded ligation, which provide enhanced error correction and remove false positives.
The new kit will be featured at the upcoming Advances in Genome Biology and Technology (AGBT) conference in Marco Island, Florida, as part of presentations by IDT staff scientists, and by The McDonnell Genome Institute (MGI) at Washington University, which will preview early access data of the kit.
“Our early test results using the Prism kit has enabled acquisition of successful libraries from some very challenging samples recalcitrant to many other methods,” said Bob Fulton, Director of Technology Development at The McDonnell Genome Institute at Washington University.
IDT is an operating company within Danaher Corporation’s (NYSE: DHR) Life Sciences platform. For more information, please visit www.idtdna.com
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Integrated DNA Technologies, Inc. (IDT)
develops, manufactures, and markets nucleic acid products for the life sciences industry in the areas of academic and commercial research, agriculture, medical diagnostics, and pharmaceutical development. IDT has developed proprietary technologies for genomics applications such as next generation sequencing, CRISPR genome editing, synthetic biology, digital PCR, and RNA interference. Through its GMP services, IDT manufactures products used by scientists in researching many forms of cancer and most inherited and infectious diseases. IDT is widely recognized as the industry leader in custom nucleic acid manufacture, serving over 130,000 life sciences researchers. IDT has its manufacturing headquarters in Coralville, Iowa, USA, with additional manufacturing sites in San Diego, California, USA; Leuven, Belgium; and Singapore.
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About Danaher Corporation
is a global science and technology innovator committed to helping its customers solve complex challenges and improving quality of life around the world. Its family of world class brands has leadership positions in the demanding and attractive health care, environmental and applied end-markets. With more than 20 operating companies, including IDT, Danaher’s globally diverse team of more than 60,000 associates is united by a common culture and operating system, the Danaher Business System, and our Shared Purpose, Helping Realize Life’s Potential. For more information, please visit www.danaher.com